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Allen Discovery Center uncovers the role of accumulating mutations in the brain

 

Aging Metaphor

Researchers at the Allen Discovery Center at Boston Children's Hospital and Harvard University have published a technical tour-de-force that may help explain neurodegeneration and everyday "senior moments," thanks to single-neuron whole-genome sequencing.


Read more about the work being done by Christopher A. Walsh, M.D., Ph.D. and colleagues on our website.


Join us for Exploring Frontiers: Rethinking the Neuroimmune System

 

Exploring Frontiers Neuroimmune

Join us for an afternoon seminar on Tuesday, April 17, 2018 highlighting two leading experts — Jonathan Kipnis, University of Virginia and Michal Schwartz, Weizmann Institute for Science — who are exploring the link between the immune and nervous systems. The seminar will begin at 3:30pm in the Allen Institute Auditorium, and will be followed by a networking reception.

Learn more about the event and register on our website.


Researchers rescue embryos from brain defects by re-engineering cellular voltage patterns

 

Bioelectricity rescue

Researchers at our Allen Discovery Center at Tufts University have demonstrated for the first time that bioelectrical patterns during development can be predicted, mapped, and manipulated to prevent defects caused by harmful substances such as nicotine.

Read the announcement from Tufts University.

 

 


New frontiers in aging research

 

Horvath Aging Image

Allen Distinguished Investigator Steve Horvath and his colleagues have made a surprising discovery about two seeming distinct aging clocks: the telomere clock, which measures age based on the length of telomeres, and the epigenetic clock, which measures age based on modifications to DNA. The research challenges the notion that one can stop aging by maintaining longer telomeres, and has beenn published in the journal Nature Communications.

Learn more about the recent publication.


Pioneering advances in active genetics

 

Ethan Bier with flies, Photo Credit to Erik Jepsen

New active genetics research from Allen Distinguished Investigator Ethan Bier and colleagues opens a new frontier for controlling genetic inheritance and genome engineering.

Read the news article from UC San Diego.

*Photo credit: Erik Jepsen, UC San Diego Publications

 


IN THE NEWS

Allen Institute adds artist-in-residence to interact with scientists and provoke mutual inspiration
GeekWire, March 21, 2018

Altering frog embryos' bioelectric patterns 'rescued' them from birth defects
Fierce BioTech, March 12, 2018

Protein Saves Embryos from Nicotine
Biocompare, March 9, 2018

Brainless Embryos Suggest Bioelectricity Guides Growth
Quanta Magazine, February 2018

He makes tadpoles with eyes on their tails. Could that one day help solve birth defects in humans?
STAT, January 2018


 

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